abstract：:Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of ap...

journal_title：Psychoneuroendocrinology

authors： Buller KM,Crane JW,Spencer SJ,Day TA

更新日期：2003-08-01 00:00:00

abstract：:Menstrually related symptoms and disorders are multidimensional and affect diverse physiologic systems. Elucidation of the pathophysiologic mechanisms of these disorders should allow for a more precise diagnosis, and provide direction for targeted therapeutic interventions. Several biologic mechanisms that underlie me...

journal_title：Psychoneuroendocrinology

authors： Halbreich U

更新日期：2003-08-01 00:00:00

abstract：:The present study evaluates the effects of one year of discontinuation and one year of growth hormone (GH) treatment on quality of life (QoL) in young adults with childhood-onset growth hormone deficiency (CO-GHD). Twenty-two subjects (14 males, 8 females; 11 isolated growth hormone deficient [IGHD], 11 multiple pitui...

journal_title：Psychoneuroendocrinology

authors： Stouthart PJ,Deijen JB,Roffel M,Delemarre-van de Waal HA

更新日期：2003-07-01 00:00:00

abstract：:Previous studies have shown that the regulation of hunger and satiety is accompanied by coordinate changes in cortical excitability. Starved subjects show a transient negative shift in the scalp-recorded cortical direct current (DC-)potential in the beginning of eating, indicating increased cortical excitability. With...

journal_title：Psychoneuroendocrinology

authors： Hallschmid M,Gais S,Meinert S,Born J

更新日期：2003-05-01 00:00:00

abstract：:Sex differences in schizophrenia can be caused by the disease process itself, by genetic and hormonal differences, by differences in the maturation and morphology of the brain and in age- and gender-specific behavioural patterns. These hypotheses will be tested on the major results reported in the literature as well a...

journal_title：Psychoneuroendocrinology

authors： Häfner H

更新日期：2003-04-01 00:00:00

abstract：:The rat forced swim test (FST) is a model that is used extensively as a screening test for antidepressant activity. It has previously been reported that thorough analysis of behaviour in this model reveals two distinct types of active response - climbing and swimming - and that these are separately evoked by re-uptake...

journal_title：Psychoneuroendocrinology

authors： Kelliher P,Kelly JP,Leonard BE,Sánchez C

更新日期：2003-04-01 00:00:00

abstract：:Intravenous injection of the cholecystokinin (CCK)-B receptor agonist, pentagastrin, produces robust, dose-dependent release of adrenocorticotropin (ACTH) and cortisol, supporting the hypothesis that CCK-B agonists pharmacologically activate the hypothalamic-pituitary-adrenal (HPA) axis. The mechanism of activation an...

journal_title：Psychoneuroendocrinology

authors： Abelson JL,Young EA

更新日期：2003-02-01 00:00:00

abstract：:Cognitive impairment has long been recognized as central to the abnormalities that occur in schizophrenia, since neurocognitive deficits are predictive of a number of outcome indices, and they pose a significant obstacle to any attempts at social rehabilitation. This raises the possibility that treatments producing im...

journal_title：Psychoneuroendocrinology

authors： Kasper S,Resinger E

更新日期：2003-01-01 00:00:00

abstract：:Glucose and insulin may play an important role in the pathophysiology and symptomatology of Alzheimers disease (AD), and prior studies suggest interactions among glucose, insulin, gender and apolipoprotein E genotype. We analyzed the relationship between steroid-induced glucose elevation and gender, presence of the ap...

journal_title：Psychoneuroendocrinology

authors： Aisen PS,Berg JD,Craft S,Peskind ER,Sano M,Teri L,Mulnard RA,Thomas RG,Thal LJ

更新日期：2003-01-01 00:00:00

abstract：:It has been suggested that the immune-endocrine communication plays an important role in development and progression of multiple sclerosis (MS). Interferon beta (IFN beta-1b) treatment is the therapy of choice in patients suffering from relapsing remitting or secondary chronic progressive multiple sclerosis. While typ...

journal_title：Psychoneuroendocrinology

authors： Goebel MU,Baase J,Pithan V,Exton M,Saller B,Schedlowski M,Limmroth V

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine if children with fragile X syndrome, who typically demonstrate a neurobehavioral phenotype that includes social anxiety, withdrawal, and hyper-arousal, have increased levels of cortisol, a hormone associated with stress. The relevance of adrenocortical activity to th...

journal_title：Psychoneuroendocrinology

authors： Hessl D,Glaser B,Dyer-Friedman J,Blasey C,Hastie T,Gunnar M,Reiss AL

更新日期：2002-10-01 00:00:00

abstract：:Depression is a common problem in multiple sclerosis (MS) and affects about 50% of MS patients. Since a dysregulation of cytokine levels has been implicated in the pathogenesis of MS and alterations in cytokine serum levels have been found in depressive illness, we examined the relationship between depressive symptoms...

journal_title：Psychoneuroendocrinology

authors： Kahl KG,Kruse N,Faller H,Weiss H,Rieckmann P

更新日期：2002-08-01 00:00:00

abstract：:Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction. PNMT identity was subsequently verified by Southern blots. Localization of the spleen cells res...

journal_title：Psychoneuroendocrinology

authors： Jelokova J,Rusnak M,Kubovcakova L,Buckendahl P,Krizanova O,Sabban EL,Kvetnansky R

更新日期：2002-07-01 00:00:00

abstract：:Overactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been frequently described in depression. Due to the closed-loop nature of the HPA axis, one possible cause of this overactivity may be a defect in negative feedback regulation, in particular an abnormality of the glucocorticoid receptor (GR). In the pre...

journal_title：Psychoneuroendocrinology

authors： Cotter PA,Mulligan OF,Landau S,Papadopoulos A,Lightman SL,Checkley SA

更新日期：2002-05-01 00:00:00

abstract：:Numerous studies over the last few decades have successfully utilized "psychological" stressors to examine stress-induced cortisol release as a function of the hypothalamic-pituitary-adrenal (HPA) cascade. In contrast, research examining the effect emotionally-laden stressors may have on cortisol release is scarce. Mo...

journal_title：Psychoneuroendocrinology

authors： Nejtek VA

更新日期：2002-04-01 00:00:00

abstract：:Cocaine stimulates the release of adrenocorticotropin hormone (ACTH) and cortisol in both clinical and preclinical studies, but the temporal sequence of cocaine-induced changes in other hormones and affective states is unclear. The purpose of this study was to analyze the pattern and temporal concordance of cocaine-in...

journal_title：Psychoneuroendocrinology

authors： Mendelson JH,Mello NK,Sholar MB,Siegel AJ,Mutschler N,Halpern J

更新日期：2002-01-01 00:00:00

abstract：:Use or abuse of licit and illicit substances is often associated with environmental stress. Current clinical evidence clearly demonstrates neurobehavioral, somatic growth and developmental deficits in children born to drug-using mothers. However, the effects of environmental stress and its interaction with prenatal dr...

journal_title：Psychoneuroendocrinology

authors： Thadani PV

更新日期：2002-01-01 00:00:00

abstract：:The relationship between immune activation and the development of early depressive symptoms were studied in 33 cancer patients undergoing cytokine therapy. Patients were treated either with subcutaneous IL-2 administered alone (n=13) or in association with IFN-alpha (n=5), or with IFN-alpha alone administered subcutan...

journal_title：Psychoneuroendocrinology

authors： Capuron L,Ravaud A,Gualde N,Bosmans E,Dantzer R,Maes M,Neveu PJ

更新日期：2001-11-01 00:00:00

abstract：:Several lines of evidence suggest a role for dopamine in the control of suicidal behaviour. Previously, we suggested an involvement of D2-dopaminergic function in the biology of suicide by demonstrating a smaller growth hormone (GH) response to apomorphine, a dopaminergic agonist, in depressed patients who later died ...

journal_title：Psychoneuroendocrinology

authors： Pitchot W,Hansenne M,Gonzalez Moreno A,Pinto E,Reggers J,Fuchs S,Pirard S,Ansseau M

更新日期：2001-10-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a steroid that shows a marked age-related decline in humans. Previous research suggests potential for DHEA replacement in old age to enhance cognition and well-being. We conducted a clinical trial to test these hypotheses in a non-clinical sample of 46 men aged 62-76. Participants rece...

journal_title：Psychoneuroendocrinology

authors： van Niekerk JK,Huppert FA,Herbert J

更新日期：2001-08-01 00:00:00

abstract：:Exposure to chronic stress is thought to play an important role in the etiology of depression. In this disorder, a disrupted negative feedback response to exogenous glucocorticoids on cortisol secretion has been indicated. However, the regulation of glucocorticoid negative feedback by chronic stress is not fully under...

journal_title：Psychoneuroendocrinology

authors： Mizoguchi K,Yuzurihara M,Ishige A,Sasaki H,Chui DH,Tabira T

更新日期：2001-07-01 00:00:00

abstract：:The aim of this research was study the role of psychosocial factors in exacerbations of asthma in adults induced by upper respiratory tract infections (URTIs). It involved a longitudinal study (one year) of 92 adults with asthma. The volunteers were 27 men and 65 women 19-46 years of age with a mean duration of wheeze...

journal_title：Psychoneuroendocrinology

authors： Smith A,Nicholson K

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Little is known about the relationship between endogenous central nervous system (CNS) testosterone and any psychiatric syndrome. The goal of this study was to screen for potential abnormalities in CNS testosterone levels in patients with post-traumatic stress disorder (PTSD) and/or tobacco dependence. METH...

journal_title：Psychoneuroendocrinology

authors： Mulchahey JJ,Ekhator NN,Zhang H,Kasckow JW,Baker DG,Geracioti TD Jr

更新日期：2001-04-01 00:00:00

abstract：:Mature rats were given lesions of the hippocampus (HIPPO), subiculum (SUBIC) or fimbria-fornix (FIFO) and then received the mild chronic stressors of food deprivation and isolation housing for ten months prior to testing. Group differences in circadian activity were investigated along with locomotion elicited by amphe...

journal_title：Psychoneuroendocrinology

authors： Bratt AM,Kelley SP,Knowles JP,Barrett J,Davis K,Davis M,Mittleman G

更新日期：2001-02-01 00:00:00

abstract：:Apart from its action as gonadotropin releasing factor, luteinizing hormone-releasing hormone (LHRH) is a potent regulator of sexual behaviour in animals. The present study aimed to assess a similar role of LHRH for sexuality in humans. In a double-blind placebo-controlled and randomized study, effects of human LHRH a...

journal_title：Psychoneuroendocrinology

authors： Perras B,Smolnik R,Fehm HL,Born J

更新日期：2001-01-01 00:00:00

abstract：:Recent studies have demonstrated that the free cortisol response to awakening can serve as a useful index of hypothalamus-pituitary-adrenal axis (HPA) activity. This endocrine marker is rather consistent, shows good intraindividual stability across time and appears to be able to uncover subtle changes in HPA regulatio...

journal_title：Psychoneuroendocrinology

authors： Wüst S,Federenko I,Hellhammer DH,Kirschbaum C

更新日期：2000-10-01 00:00:00

abstract：:This study was designed to investigate the relationship between selective attention to social threat and neuroendocrine activity. Selective attention to social threat was measured using a supraliminal (unmasked) and a subliminal (masked) version of a pictorial emotional Stroop task, comparing color-naming latencies of...

journal_title：Psychoneuroendocrinology

authors： van Honk J,Tuiten A,van den Hout M,Koppeschaar H,Thijssen J,de Haan E,Verbaten R

更新日期：2000-08-01 00:00:00

abstract：:We have previously shown that serum gonadotropins, particularly LH, decline after acute exercise in male volunteers. The mechanism for this decline is unknown. Plasma leptin and IGF-I concentrations were measured in seven male volunteers after acute exercise to exhaustion using the Bruce protocol. Leptin concentration...

journal_title：Psychoneuroendocrinology

authors： Elias AN,Pandian MR,Wang L,Suarez E,James N,Wilson AF

更新日期：2000-07-01 00:00:00

abstract：:The present study examines the hypothesis that exposure to anabolic-androgenic steroids (AAS) during adolescent development predisposes hamsters to heightened levels of aggressive behavior by influencing the anterior hypothalamic-arginine vasopressin (AH-AVP) neural system. To test this, adolescent male hamsters (Meso...

journal_title：Psychoneuroendocrinology

authors： Harrison RJ,Connor DF,Nowak C,Nash K,Melloni RH Jr

更新日期：2000-05-01 00:00:00

abstract：:Central dopaminergic dysfunction has been suggested to be involved in the pathogenesis of obsessive compulsive disorder (OCD). In 15 patients with OCD and in 15 age-sex matched controls we evaluated the dopamine (DA) function by measuring the cortisol (CORT) responses to stimulation with the DA agonist apomorphine (AP...

journal_title：Psychoneuroendocrinology

authors： Brambilla F,Perna G,Bussi R,Bellodi L

更新日期：2000-04-01 00:00:00

abstract：:Depressive illness is associated with loss of the usual regulation of stress-responsive hormonal and neurotransmitter systems, and antidepressants have intrinsic effects reducing the activity of these systems. Abrupt interruption of treatment with some antidepressants has been associated with a self-limited syndrome o...

journal_title：Psychoneuroendocrinology

authors： Michelson D,Amsterdam J,Apter J,Fava M,Londborg P,Tamura R,Pagh L

更新日期：2000-02-01 00:00:00

abstract：:In order to determine whether central serotonin (5-HT) activity is related to sensitivity of insulin receptors, 19 healthy volunteers with normal basal glycemia and HbAlc were studied. The relationship between prolactin response to D-fenfluramine (delta PRL) in a challenge test and metabolic clearance rates (MCR) of g...

journal_title：Psychoneuroendocrinology

authors： Horácek J,Kuzmiaková M,Höschl C,Andĕl M,Bahbonh R

更新日期：1999-11-01 00:00:00

abstract：:No inclusive or satisfactory biomedical explanation for chronic fatigue syndrome (CFS) has as yet been forwarded. Recent research suggests that a dysregulated hypothalamic-pituitary-adrenal axis (HPA) may be contributory, and in particular that there may be diminished forward drive and adrenal under-stimulation. In th...

journal_title：Psychoneuroendocrinology

authors： Scott LV,Teh J,Reznek R,Martin A,Sohaib A,Dinan TG

更新日期：1999-10-01 00:00:00

abstract：:Prenatal ethanol exposure produces hypothalamic-pituitary-adrenal (HPA) hyperresponsiveness to stressors. The present study tested the hypothesis that decreased corticosteroid receptor densities at HPA feedback sites may play a role in deficient feedback inhibition and the resultant HPA hyperresponsiveness that is obs...

journal_title：Psychoneuroendocrinology

authors： Kim CK,Yu W,Edin G,Ellis L,Osborn JA,Weinberg J

更新日期：1999-08-01 00:00:00

abstract：:This study examined the effects of a 10-week cognitive-behavioral stress management (CBSM) intervention on dehydroepiandrosterone sulfate (DHEA-S) levels and the ratio of cortisol to DHEA-S (cortisol/DHEA-S), potential surrogate adrenal markers of HIV disease progression, in relation to alterations in mood and distres...

journal_title：Psychoneuroendocrinology

authors： Cruess DG,Antoni MH,Kumar M,Ironson G,McCabe P,Fernandez JB,Fletcher M,Schneiderman N

更新日期：1999-07-01 00:00:00

abstract：:Menstrual synchrony has been typically studied among women who live together: dormitory roommates or family members sharing a bedroom or living in the same house. The current study examined menstrual synchrony in 51 pairs of women working together under conditions optimally conducive to synchrony. They had been togeth...

journal_title：Psychoneuroendocrinology

authors： Weller L,Weller A,Koresh-Kamin H,Ben-Shoshan R

更新日期：1999-05-01 00:00:00

abstract：:Prior studies have reported cortisol secretion to be primarily influenced by negative affect, but less is known about cortisol activity during states of activation involving increased positive affect and decreased negative affect. On separate days, 30 healthy young men experienced: an activating and humorous video; a ...

journal_title：Psychoneuroendocrinology

authors： Buchanan TW,al'Absi M,Lovallo WR

更新日期：1999-02-01 00:00:00

abstract：:The effects of pregnancy on cognition and mood were examined using a repeated-measures design. Nineteen women, average age 33, were tested with a comprehensive neuropsychological battery during their last 2 months of pregnancy and again within 2 months of delivery. Blood samples were obtained from all subjects and ass...

journal_title：Psychoneuroendocrinology

authors： Buckwalter JG,Stanczyk FZ,McCleary CA,Bluestein BW,Buckwalter DK,Rankin KP,Chang L,Goodwin TM

更新日期：1999-01-01 00:00:00

abstract：:The evolution of the autonomic nervous system provides an organizing principle to interpret the adaptive significance of mammalian affective processes including courting, sexual arousal, copulation, and the establishment of enduring social bonds. According to the Polyvagal Theory (Porges, 1995, 1996, 1997), the well-d...

journal_title：Psychoneuroendocrinology

authors： Porges SW

更新日期：1998-11-01 00:00:00

abstract：:Patients with hyperthyroidism may show impaired performance on several neuropsychological tests that require complex visual discrimination, conceptualization, mental flexibility or organization. These neurocognitive impairments appear to be consistent with prefrontal lobe dysfunction. This pilot study was undertaken t...

journal_title：Psychoneuroendocrinology

authors： Bhatara VS,Tripathi RP,Sankar R,Gupta A,Khushu S

更新日期：1998-08-01 00:00:00